{"id":10260,"date":"2025-12-21T12:52:50","date_gmt":"2025-12-21T10:52:50","guid":{"rendered":"https:\/\/drkartsiounis.gr\/el\/?p=10260"},"modified":"2025-12-21T12:52:50","modified_gmt":"2025-12-21T10:52:50","slug":"%ce%ba%ce%b1%cf%84%ce%b1%ce%bd%ce%bf%ce%b7%cf%83%ce%b7-%cf%84%ce%b7%cf%83-%ce%b3%ce%b5%ce%bd%ce%b5%cf%84%ce%b9%ce%ba%ce%b7%cf%83-%cf%80%cf%81%ce%bf%ce%b4%ce%b9%ce%b1%ce%b8%ce%b5%cf%83%ce%b7%cf%83-2","status":"publish","type":"post","link":"https:\/\/drkartsiounis.gr\/en\/%ce%ba%ce%b1%cf%84%ce%b1%ce%bd%ce%bf%ce%b7%cf%83%ce%b7-%cf%84%ce%b7%cf%83-%ce%b3%ce%b5%ce%bd%ce%b5%cf%84%ce%b9%ce%ba%ce%b7%cf%83-%cf%80%cf%81%ce%bf%ce%b4%ce%b9%ce%b1%ce%b8%ce%b5%cf%83%ce%b7%cf%83-2\/","title":{"rendered":"UNDERSTANDING THE GENETIC PREDISPOSITION TO ENDOMETRIC CANCER \u2013 LYNCH SYNDROME"},"content":{"rendered":"

Endometrial cancer is one of the most common forms of gynecological cancer, but for some women, its occurrence may be related to a genetic predisposition. Lynch syndrome, an inherited genetic disorder, is strongly associated with an increased risk of endometrial cancer as well as other malignancies. In this article, we will examine what Lynch syndrome is, how it is related to endometrial cancer, and what steps can be taken to prevent and manage it.<\/span><\/p>\n

What is Lynch syndrome and how is it related to endometrial cancer?<\/b><\/h3>\n

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is a genetic disorder caused by mutations in genes responsible for DNA repair, such as MLH1, MSH2, MSH6, and PMS2. Women with Lynch syndrome have an increased risk of developing endometrial cancer, which can reach up to 60%, as well as ovarian, colorectal, and other organ cancers.<\/span><\/p>\n

What are the symptoms of endometrial cancer?<\/b><\/h3>\n

Endometrial cancer associated with Lynch syndrome may present with the same symptoms as non-hereditary cases, such as:<\/span><\/p>\n

    \n
  • Bleeding outside of menstruation or after menopause.<\/span><\/li>\n
  • Unusual vaginal discharge.<\/span><\/li>\n
  • Pain or pressure in the pelvic area.<\/span><\/li>\n<\/ul>\n

    \u00a0<\/span> Early diagnosis is critical, especially for women with a family history of Lynch syndrome or multiple cases of cancer in first-degree relatives.<\/span><\/p>\n

    Who should be tested for Lynch syndrome?<\/b><\/h3>\n

    Genetic testing for Lynch syndrome is important for women who meet the following criteria:<\/span><\/p>\n

      \n
    • History of endometrial cancer under the age of 50.<\/span><\/li>\n
    • History of colon or ovarian cancer, especially when there are other cases in the family.\u00a0<\/span><\/li>\n
    • Multiple cases of cancer in a family (colon, endometrial, stomach or ovarian).<\/span><\/li>\n<\/ul>\n

      \u00a0<\/span> The test involves testing blood or tissue to identify mutations in DNA repair genes.<\/span><\/p>\n

      How can endometrial cancer be prevented in women with Lynch syndrome?<\/b><\/h3>\n

      Prevention is vital for women with Lynch syndrome. Key strategies include:<\/span><\/p>\n

        \n
      1. Regular monitoring:<\/b>\n
          \n
        • Annual gynecological examination.<\/span><\/li>\n
        • Pelvic ultrasound and CA-125 test to detect ovarian cancer.<\/span><\/li>\n
        • Endometrial biopsy at regular intervals to detect early changes.<\/span><\/li>\n<\/ul>\n<\/li>\n
        • Preventive surgery:<\/b>\n
            \n
          • In women who have completed childbearing, removal of the uterus (hysterectomy) and ovaries can significantly reduce the risk of developing cancer.<\/span><\/li>\n<\/ul>\n<\/li>\n
          • Pharmaceutical prevention:<\/b>\n
              \n
            • Some studies have shown that the use of progestogens or contraceptives may reduce the risk of endometrial cancer.<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

              \u00a0<\/span><\/p>\n

              Treatment of endometrial cancer in women with Lynch syndrome<\/b><\/h3>\n

              Treatment of endometrial cancer in women with Lynch syndrome is individualized and includes:<\/span><\/p>\n

                \n
              • Surgical treatment:<\/b> Total hysterectomy and removal of ovaries is the main treatment.<\/span><\/li>\n
              • Targeted therapies:<\/b> Drugs that specifically target DNA mutations have shown positive results.<\/span><\/li>\n
              • Immunotherapy:<\/b> Strengthens the immune system for better anti-cancer action.\u00a0<\/span><\/li>\n<\/ul>\n

                \u00a0<\/p>\n

                What women with Lynch syndrome need to know<\/b><\/h3>\n

                Knowing your genetic predisposition to endometrial cancer helps in making decisions about prevention and treatment. It is important for women with a family history to consult with specialized doctors and undergo genetic testing.<\/span><\/p>\n

                Conclusion<\/b><\/h3>\n

                Lynch syndrome is one of the main genetic risk factors for endometrial cancer, but early detection and prevention can make a difference. With regular screenings, preventive interventions, and personalized treatment, women with Lynch syndrome can protect their health and live without fear. If you have a family history of cancer, contact us to determine the appropriate action plan.<\/span><\/p>","protected":false},"excerpt":{"rendered":"

                Endometrial cancer is one of the most common forms of gynecological cancer, but for some women, its occurrence may be related to a genetic predisposition. Lynch syndrome, an inherited genetic disorder, is strongly associated with an increased risk of endometrial cancer as well as other malignancies. In this article, we will examine what Lynch syndrome is, how it is related to endometrial cancer, and what steps can be taken to prevent and manage it. What is Lynch syndrome and how is it related to endometrial cancer Lynch syndrome, also known as hereditary non-polypoid carcinoma [\u2026]<\/p>","protected":false},"author":4,"featured_media":10259,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jf_save_progress":"","footnotes":""},"categories":[358],"tags":[279,359,417,270,418],"class_list":["post-10260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-358","tag-drkartsiounis","tag-359","tag-417","tag-270","tag--lynch"],"_links":{"self":[{"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/posts\/10260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/comments?post=10260"}],"version-history":[{"count":1,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/posts\/10260\/revisions"}],"predecessor-version":[{"id":10261,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/posts\/10260\/revisions\/10261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/media\/10259"}],"wp:attachment":[{"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/media?parent=10260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/categories?post=10260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drkartsiounis.gr\/en\/wp-json\/wp\/v2\/tags?post=10260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}